CITI Social and Behavioral Training Practice Test 2026 - Complete Exam Prep

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What is risk/benefit analysis in IRB review, and give an example of a social/behavioral study with a favorable risk-benefit ratio?

Weighs potential benefits against risks; example: anonymous survey on stress that preserves privacy and has minimal risk but yields valuable knowledge.

Risk/benefit analysis in IRB review means weighing potential benefits to participants or society against potential risks or harms to participants, with the aim of ensuring that the benefits justify the risks and that any risks are minimized through safeguards.

An example of a social/behavioral study with a favorable risk-benefit ratio is an anonymous online survey about stress and coping. Participation involves minimal risk: no physical procedures, responses are kept confidential, and sensitive data are protected. The study can yield valuable insights into how different stressors affect well-being and can inform interventions or policies to reduce stress at the population level. Because privacy protections keep risk low while the potential knowledge gains are meaningful, the overall balance is favorable.

This isn’t about considering risks alone, and there isn’t a fixed margin by which benefits must exceed risks. Societal benefits are part of the evaluation, and benefits and risks are weighed in context, with safeguards to minimize risk.

It only considers the risks to participants.

It requires benefits to always exceed risks by a fixed margin.

Societal benefits are not considered.

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